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Genetic predisposition to colorectal cancer

โœ Scribed by de la Chapelle, Albert


Book ID
109947252
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
211 KB
Volume
4
Category
Article
ISSN
1474-1776

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Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome linked to DNA-mismatch-repair (MMR) gene defects, which also account for microsatellite instability (MSI) in tumour tissues. Diagnosis is based mainly on family history, according to widely accepted criteria (Amste