The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex-and age-matched normal controls. As a result of the cy
Genetic predisposition to breast cancer
β Scribed by Mark H. Skolnick; Lisa A. Cannon-Albright
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 881 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA doubleβstrand breaks. Recently, a truncating mutation in