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Common fragile site expression and genetic predisposition to breast cancer

✍ Scribed by Gülşah Çeçener; Ünal Egeli; Ismet Taşdelen; Berrin Tunca; Hakan Duman; Ayhan Kizil

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 140 KB
Volume: 18
Category: Article
ISSN: 0270-3211
DOI: 10.1002/(sici)1520-6866(1998)18:6<279::aid-tcm2>3.0.co;2-u

No coin nor oath required. For personal study only.

✦ Synopsis

The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex-and age-matched normal controls. As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression frequencies of fragile sites detected in patients with breast cancer and their first-degree relatives were found to be significantly higher than those in the control group. Our findings indicate an increased genetic instability in women with breast carcinomas and their relatives. Therefore, fragile sites may be used as a reliable marker for defining genetic susceptibility to cancer in general.

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