✦ LIBER ✦

Breast cancer: Genetic predisposition and exposure to radiation

✍ Scribed by L. Michelle Bennett

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 89 KB
Volume: 26
Category: Article
ISSN: 0899-1987
DOI: 10.1002/(sici)1098-2744(199911)26:3<143::aid-mc2>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

The identification of breast cancer susceptibility genes, such as BRCA1, BRCA2, ATM, and p53, has been accompanied by the examination of the effects of radiation in combination with genetic mutations at these loci. Women at high risk for developing breast cancer may respond differently than the general population to low-and high-dose radiation exposures associated with screening and treatment. Epidemiologic studies are being performed to investigate the effects of radiation on subsequent breast cancer development in genetically predisposed individuals. Mouse strains with specific genetic modifications are being created to study the consequence of both inherited mutations and radiation on mammary gland carcinogenesis. Finally, studies investigating DNA damage±response pathways after radiation exposure are being performed. Recent work on the effects of several known or suspected breast cancer susceptibility genes, alone or in combination with radiation, is presented here, and directions for future research are considered.

📜 SIMILAR VOLUMES

Common fragile site expression and genet

Common fragile site expression and genetic predisposition to breast cancer

✍ Gülşah Çeçener; Ünal Egeli; Ismet Taşdelen; Berrin Tunca; Hakan Duman; Ayhan Kiz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 1 views

The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex-and age-matched normal controls. As a result of the cy

Chromosome 5 aberrations and genetic pre

Chromosome 5 aberrations and genetic predisposition to lung cancer

✍ Xifeng Wu; Yin Zhao; Bonnie L. Kemp; Christopher I. Amos; Michael J. Siciliano; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 163 KB 👁 1 views

In this study, we aimed to confirm the finding that chromosome 5 aberrations are predisposing factors for lung cancer. The study population consisted of 118 previously untreated lung cancer patients and 101 healthy controls. Lymphocytes were treated with bleomycin for 5 hr and then allowed to recove

Inherited genetic predisposition in brea

Inherited genetic predisposition in breast cancer : A population-based perspective

✍ Timothy R. Rebbeck 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 2 views

Two classes of inherited susceptibility genes may be considered in the etiology of breast and other common cancers. First, genes have been identified that confer a high degree of breast cancer (BC) risk, usually associated with hereditary syndromes, but disease-associated germline variants in these

Occupational exposure to radiation as a

Occupational exposure to radiation as a cancer hazard

✍ Victor E. Archer 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 2 views

There is much experimental data which indicates that ionizing radiation is a very potent carcinogenic agent. Most types of carcinoma can be produced by radiation. Carcinoma is apparently induced through a single or a series of mutations in somatic cells. Radiologists have excess leukemia and other m

Childhood and adult cancer after intraut

Childhood and adult cancer after intrauterine exposure to ionizing radiation

✍ Boice, John D.; Miller, Robert W. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB 👁 1 views

Since the reports in 1956 and 1958 that in utero radiation was associated with an increased risk of leukemia and solid cancers during childhood, this issue has been debated. Many epidemiological studies have been performed. Evidence for a causal association derives almost entirely from case-control

Prophylactic mastectomy and inherited pr

Prophylactic mastectomy and inherited predisposition to breast carcinoma

✍ Kevin S. Hughes; Moshe Z. Papa; Timothy Whitney; Robert McLellan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB

Relative to her risk of breast carcinoma, the woman with a BRCA1 or BRCA2 gene mutation can be managed either by intensive screening (with or without chemoprevention) or by prophylactic mastectomy. Although it would be preferable to avoid prophylactic surgery, the current level of screening technolo