## Abstract The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA doubleβstrand breaks. Recently, a truncating mutation in
Genetic mechanisms in cancer predisposition. Report of a cancer family
β Scribed by Lorraine F. Meisner; Enid Gilbert; Hania W. Ris; Gary Haverty
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 1021 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
1 . E:pstein-Barr Virus Antihody Titers and N1.
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Two classes of inherited susceptibility genes may be considered in the etiology of breast and other common cancers. First, genes have been identified that confer a high degree of breast cancer (BC) risk, usually associated with hereditary syndromes, but disease-associated germline variants in these
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