𝔖 Bobbio Scriptorium
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Loss of heterozygosity of the oestrogen receptor gene in breast cancer

✍ Scribed by Iwase, H; Greenman, JM; Barnes, DM; Bobrow, L; Hodgson, S; Mathew, CG

Book ID
109837213
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
513 KB
Volume
71
Category
Article
ISSN
0007-0920

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The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit