Loss of Heterozygosity of Chromosome 10p in Human Gliomas
β Scribed by Alec C. Kimmelman; Donald A. Ross; Bertrand C. Liang
- Book ID
- 115613233
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 143 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0888-7543
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cytogenetic and RFLP studies have shown that chromosome I0 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determ
Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two