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Loss of heterozygosity for 10q loci in human gliomas

✍ Scribed by B. K. Ahmed Rasheed; Gregory N. Fuller; Allan H. Friedman; Darell D. Bigner; Dr. Sandra H. Bigner

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 730 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050111

No coin nor oath required. For personal study only.

✦ Synopsis

Cytogenetic and RFLP studies have shown that chromosome I0 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determine the smallest common deletion interval on this chromosome.

Seven tumors did not lose heterozygosity for any of the markers. Twenty-three tumors lost an allele for all the informative loci. In I I tumors heterozygosity was maintained at some loci and lost at other loci, indicating partial deletion of chromosome 10. The common region of deletion in these I I tumors was located in IOq24-q26 between the markers pHUK-8 and pMCTI22.2. Genes Chrom Cancer 5:75-82 (1992). @ 1992 Wiley-Liss, Inc.

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