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Loss of heterozygosity for distal markers on 22q in human gliomas

✍ Scribed by Juan A. Rey; M. Josefa Bello; Ana M. Jimenez-lara; Jesus Vaquero; M. Elena Kusak; José M. de Campos; José L. Sarasa; Angel Pestana

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
747 KB
Volume
51
Category
Article
ISSN
0020-7136

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✦ Synopsis

Loss of constitutional heterozygosity as determined through the analysis of restriction-fragment-length polymorphism (RFLP) on tumoral and constitutional DNA has proven to be helpful to delimit the location of tumor-suppressor genes in the human genome. In malignant gliomas this approach indicates that

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