Loss of heterozygosity analysis in malignant gliomas
β Scribed by Masahiro Mizoguchi; Daisuke Kuga; Yanlei Guan; Nobuhiro Hata; Akira Nakamizo; Koji Yoshimoto; Tomio Sasaki
- Publisher
- Springer Japan
- Year
- 2011
- Tongue
- English
- Weight
- 317 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1433-7398
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cytogenetic and RFLP studies have shown that chromosome I0 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determ
Loss of constitutional heterozygosity as determined through the analysis of restriction-fragment-length polymorphism (RFLP) on tumoral and constitutional DNA has proven to be helpful to delimit the location of tumor-suppressor genes in the human genome. In malignant gliomas this approach indicates t