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Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer

✍ Scribed by Maliekal, Tessy T; Antony, Marie-Lue; Nair, Asha; Paulmurugan, Ramasamy; Karunagaran, Devarajan

Book ID
110067893
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
343 KB
Volume
22
Category
Article
ISSN
0950-9232

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BACKGROUND. Loss of heterozygosity (LOH) on chromosome arm 18q is common in sporadic prostate cancer and may be involved in cancer development through inactivation of tumor-suppressor genes (TSG). Recent identification, at 18q21.1, of MADR2/Smad2, a key component in transforming growth factor ␀ (TGF