TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines
✍ Scribed by Fink, Stephen P; Mikkola, Debra; Willson, James K V; Markowitz, Sanford
- Book ID
- 110067251
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 372 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Transforming growth factor‐beta 1 (TGF‐β1) is an important growth inhibitor of epithelial cells and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. TGF‐β1 signals through the TGF‐β type I and type II receptors, and activates
## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno