Localized q-space imaging of the mouse brain

✍ Scribed by Martin D. King; J. Houseman; D. G. Gadian; A. Connelly

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 870 KB
• Volume: 38
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910380612

✦ Synopsis

Abstract

Localized q‐space imaging was used to obtain water displacement profiles from mouse brain. These profiles take the form of unidirectional diffusive displacement probability distributions. Two groups of mice were studied, a normal group and a group in which surgery had been performed to produce a unilateral reduction in the supply of blood to the forebrain. q‐Space measurements were made both in vivo and postmortem. The displacement profiles were characterized using the summary parameter prob[d < 10], which is the proportion of water molecules that undergo a net diffusive displacement that is less than ±10 μm, during the diffusion period (50 ms). The range of prob[d < 10] values in the normal group was 0.71 to 0.77 in vivo compared with 0.78 to 0.87 in the impaired hemisphere of the surgically treated group. An increase in prob[d < 10] occurred postmortem to yield values in the range 0.79 to 0.81 and 0.80 to 0.89 in the normal and surgically treated group, respectively. These observations are consistent with the diffusion‐weighted image intensity changes that occur after a period of ischemia.