## Abstract Localized __q__βspace imaging was used to obtain water displacement profiles from mouse brain. These profiles take the form of unidirectional diffusive displacement probability distributions. Two groups of mice were studied, a normal group and a group in which surgery had been performed
q-Space imaging of the brain
β Scribed by Martin D. King; John Houseman; Simon A. Roussel; Nicholas Van Bruggen; Stephen R. Williams; David G. Gadian
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 790 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0740-3194
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β¦ Synopsis
Abstract
~q~βSpace imaging (Callaghan, J. Magn. Reson. 88,493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherentβdisplacement probability density distribution. Two groups of mice were studied, a normal group and one in which surgery had been performed to reduce the supply of blood to the forebrain. In the normal group the incoherent displacement of water was reducedpostmortem. Four of the surgically treated mice yielded displacement profiles that resembled those obtained postmortem; the remaining two were near normal. This study demonstrates the feasibility of in vivo qβspace imaging. The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusionβweighted imaging.
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