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q-Space imaging of the brain

✍ Scribed by Martin D. King; John Houseman; Simon A. Roussel; Nicholas Van Bruggen; Stephen R. Williams; David G. Gadian


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
790 KB
Volume
32
Category
Article
ISSN
0740-3194

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✦ Synopsis


Abstract

~q~‐Space imaging (Callaghan, J. Magn. Reson. 88,493 (1990)) has been used to obtain mouse brain water displacement profiles. These profiles take the form of a unidirectional incoherent‐displacement probability density distribution. Two groups of mice were studied, a normal group and one in which surgery had been performed to reduce the supply of blood to the forebrain. In the normal group the incoherent displacement of water was reducedpostmortem. Four of the surgically treated mice yielded displacement profiles that resembled those obtained postmortem; the remaining two were near normal. This study demonstrates the feasibility of in vivo q‐space imaging. The displacement profile changes that occur subsequent to an interruption of the forebrain blood supply are consistent with the hyperintensity changes seen in diffusion‐weighted imaging.


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