In vivo7Li NMR imaging and localized spectroscopy of rat brain

✍ Scribed by S. Ramaprasad; J. E. O. Newton; D. Cardwell; A. H. Fowler; R. A. Komoroski

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 681 KB
• Volume: 25
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910250209

✦ Synopsis

Abstract

Lithium‐7 in vivo NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a steady level of Li from about 5 to 20 h. Localized spectroscopy on brain sections revealed no differences in Li concentration among the front, middle, and rear of the brain. The spin‐lattice relaxation time showed a single exponential decay for the head. The spin‐spin relaxation time for head showed a biexponential behavior. Using a ^1^H‐^7^Li double coil assembly,^7^Li images were generated for rat head, as was the corresponding ^1^H image for anatomic localization. The ^7^Li image (7‐mm slice thickness, 4‐mm in‐plane resolution) recorded after the last dose in a multiple ip dose protocol shows the Li distribution in the head and neck. Based on ^7^Li images, the Li level in muscle was about twice that in the brain. Variations of ^7^Li intensity level across the brain were typically small. © 1992 Academic Press, Inc.