𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vivo localized proton NMR spectroscopy of thiamine-deficient rat brain

✍ Scribed by Haakil Lee; James Tarter; George E. Holburn; Ronald R. Price; David D. Weinstein; Peter R. Martin

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
778 KB
Volume
34
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague‐Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine‐deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 ± 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose‐dependent recovery in Cho/NAA was observed.

📜 SIMILAR VOLUMES

Cerebral glucose is detectable by locali
Cerebral glucose is detectable by localized proton NMR spectroscopy in normal rat brain in Vivo
✍ M. L. Gyngell; T. Michaelis; D. Hörstermann; H. Bruhn; W. Hänicke; K. D. Merbold 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB 👁 1 views

This contribution reports the first direct and noninvasive observation of cerebral glucose in normal anesthetized rats (n = 16) using short-echo-time localized proton NMR spectroscopy (2.35 T, STEAM, TR = 6000 ms, TE = 20 ms, 125 microliters). In addition to resonances from N-acetyl aspartate (NAA),

In Vivo localized proton NMR spectroscop
In Vivo localized proton NMR spectroscopy of silicone
✍ Bettina Pfleiderer; Jerome L. Ackerman; Leoncio Garrido 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 573 KB

## Abstract ^1^H NMR localized spectroscopy (STEAM) can assess unambiguously the presence of free chemically unchanged silicone in animal tissue after injection of silicone oil. Although the signal—to—noise ratio obtained in ^1^H imaging is sufficient to detect the distribution of relatively large

In vivo7Li NMR imaging and localized spe
In vivo7Li NMR imaging and localized spectroscopy of rat brain
✍ S. Ramaprasad; J. E. O. Newton; D. Cardwell; A. H. Fowler; R. A. Komoroski 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 681 KB

## Abstract Lithium‐7 __in vivo__ NMR spectroscopy and imaging techniques have been developed at 4.7 T for rat head. The pharmacokinetics of lithium (Li) uptake in rat head has been measured using STEAM localized spectroscopy for the whole brain, which showed relatively rapid uptake of Li and a ste

Molecular self-diffusion of intracellula
Molecular self-diffusion of intracellular metabolites in rat brain in vivo Investigated by Localized Proton NMR Diffusion Spectroscopy
✍ Klaus-Dietmar Merboldt; Dirk Hörstermann; Wolfgang Hänicke; Harald Bruhn; Jens F 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 418 KB 👁 1 views

## Abstract Molecular self‐diffusion coefficients of water (0.75 ± 0.05), Nacetylaspartate (0.27 ± 0.04), creatines (0.27 ± 0.04), and cholines (0.28 ± 0.08) × 10^−5^ cm^2^ s^−1^ were obtained from localized proton NMR spectra of rat brain in vivo using diffusion‐weighted stimulated‐echo (STEAM) se