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In Vivo localized proton NMR spectroscopy of silicone

โœ Scribed by Bettina Pfleiderer; Jerome L. Ackerman; Leoncio Garrido

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
573 KB
Volume
30
Category
Article
ISSN
0740-3194

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โœฆ Synopsis

Abstract

^1^H NMR localized spectroscopy (STEAM) can assess unambiguously the presence of free chemically unchanged silicone in animal tissue after injection of silicone oil. Although the signalโ€”toโ€”noise ratio obtained in ^1^H imaging is sufficient to detect the distribution of relatively large amounts of silicone in vivo, the specificity of silicone detection can be improved by using ^1^H localized spectroscopy techniques. The sensitivity of the STEAM experiments is sufficient to detect silicone at a concentration of 0.5% in a voxel of 27 mm^3^. Preliminary results from rats with silicone gelโ€”filled implants show no detectable amounts of silicone in sites such as lymph nodes, the liver or the spleen, 3 or 6 months after implantation.

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