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In vivo measurements of bone marrow cellularity using volume-localized proton NMR spectroscopy

✍ Scribed by D. Ballon; A. Jakubowski; J. Gabrilove; M. C. Graham; M. Zakowski; C. Sheridan; J. A. Koutcher

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
643 KB
Volume
19
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Volume‐localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24‐h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P < 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases. © 1991 Academic Press, Inc.

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