𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The distribution of lithium in rat brain and muscle in vivo by 7Li NMR imaging

✍ Scribed by Richard A. Komoroski; John M. Pearce; Joseph E. O. Newton

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
437 KB
Volume
38
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The regional distribution of lithium (Li) in vivo was determined on a relative basis in the brain and muscle of rats by ^7^Li NMR imaging. Both high resolution ^7^Li NMR spectroscopy and atomic absorption spectrophotometry were performed on extracts of brain and muscle tissue from the same rats. The average in vivo results were generally in good agreement with the corresponding average in vitro results, despite the relatively low signal‐to‐noise ratio of the in vivo images. There was good agreement between the two in vitro methods of analysis, both on average and for individual animals. Significant differences were found in vivo among Li concentration ratios for the various brain regions and muscle by ^7^Li imaging, as well as by the in vitro methods.

πŸ“œ SIMILAR VOLUMES

Lithium Visibility in Rat Brain and Musc
Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging
✍ Richard A. Komoroski; John M. Pearce; Joseph E.O. Newton πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 English βš– 203 KB

The apparent concentration of lithium (Li) in vivo was determined for several regions in the brain and muscle of rats by 7 Li NMR imaging at 4.7 T with inclusion of an external standard of known concentration and visibility. The average apparent concentrations were 10.1 mM for muscle, and 4.2-5.3 mM

Localized 7Li MR spectroscopy: In vivo b
Localized 7Li MR spectroscopy: In vivo brain and serum concentrations in the rat
✍ John M. Pearce; Melvin Lyon; Richard A. Komoroski πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 97 KB πŸ‘ 1 views

## Abstract The brain concentration of lithium (Li) in treated rats was measured using a recently developed method based on in vivo ^7^Li PRESS localized MRS. Comparison was made to the corresponding serum concentration at two treatment durations. The brain and serum Li concentrations were highly c

In vivo1H and 31P NMR spectroscopy of th
In vivo1H and 31P NMR spectroscopy of the developing rat brain
✍ Kazutoshi Hida; Ingrid L. Kwee; Tsutomu Nakada πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 357 KB πŸ‘ 1 views

## Abstract The biochemical changes associated with brain maturation during the first 28 days postnatal were investigated utilizing proton and phosphorus‐31 nuclear magnetic resonance spectroscopy in rat pups __in vivo.__ Phosphocreatine was found to increase linearly during this period of developm

In vivo three-dimensional reconstruction
In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging
✍ Rong Xue; Peter C.M. van Zijl; Barbara J. Crain; Meiyappan Solaiyappan; Susumu M πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 351 KB πŸ‘ 2 views

The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo threedimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high-resolution diffusion-wei

Detection of [1,6-13C2]-glucose metaboli
Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy
✍ Robin A. de Graaf; Peter B. Brown; Graeme F. Mason; Douglas L. Rothman; Kevin L. πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 339 KB

## Abstract Localized, water‐suppressed ^1^H‐[^13^C]‐NMR spectroscopy was used to detect ^13^C‐label accumulation in cerebral metabolites following the intravenous infusion of [1,6‐^13^C~2~]‐glucose (Glc). The ^1^H‐[^13^C]‐NMR method, based on adiabatic RF pulses, 3D image‐selected in vivo spectros