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In vivo1H and 31P NMR spectroscopy of the developing rat brain

✍ Scribed by Kazutoshi Hida; Ingrid L. Kwee; Tsutomu Nakada

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
357 KB
Volume
23
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The biochemical changes associated with brain maturation during the first 28 days postnatal were investigated utilizing proton and phosphorus‐31 nuclear magnetic resonance spectroscopy in rat pups in vivo. Phosphocreatine was found to increase linearly during this period of development. Phosphomonoester was high at birth, peaked around the 10th day postnatal, and declined thereafter. N‐Acetyl‐aspartate was low at birth, increased in an approximately linear fashion, and reached adult levels by about Day 28 postnatal. Choline was high at birth and declined thereafter. Taurine, a sulfur amino acid abundant in fetal brain, was also present in high levels on the first day postnatal. Β© 1992 Academic Press, Inc.

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