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Localized 7Li MR spectroscopy and spin relaxation in rat brain in vivo

✍ Scribed by Richard A. Komoroski; John M. Pearce

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
174 KB
Volume
52
Category
Article
ISSN
0740-3194

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✦ Synopsis

Localized 7Li MR point-resolved spectroscopy (PRESS) was developed as a technique to measure lithium (Li) concentration in rat brain in vivo. Localized 7Li spectra could be obtained at 4.7 T in a 0.7-ml voxel in rat brain over the entire therapeutic range of serum Li for humans. Localized 7Li spin-lattice (T1) and spin-spin (T2) relaxation times were measured. Measured intensities were corrected for spin relaxation effects and 7Li MR visibility in vivo. The average T1 was 3.3 +/- 0.9 sec, and the average T2 was 82 +/- 20 ms. Neither T1 nor T2 correlated with brain concentration. No statistically significant change was found in either T1 or T2 from approximately 7-17 days of Li dosing.

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