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Localization of thymidine phosphorylase in breast cancer tissue

✍ Scribed by Michiya Kobayashi; Takeki Sugimoto ; Takehiro Okabayashi; Ken Okamoto; Tsutomu Namikawa; Naoshige Tochika; Toshiaki Moriki; Keijiro Araki


Book ID
106238926
Publisher
Springer
Year
2005
Tongue
English
Weight
693 KB
Volume
38
Category
Article
ISSN
0918-4287

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## Abstract Thymidine phosphorylase (TP), also known as platelet‐derived endothelial cell growth factor (PD‐ECGF), is an enzyme that catalyzes the reversible dephosphorylation of thymidine, deoxyuridine and their analogs. TP has also angiogenic properties, although the precise mechanism by which it

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We have investigated the expression of platelet-derived endothelial-cell growth factorkhymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/ dThdPase monoclonal antibody. Out of I00 invasive-ductal-carcinoma tissue samples, 39 (

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BACKGROUND. This is the first study on the quantitative assessment of thymidine phosphorylase (TP) activity in patients with nonsmall lung carcinoma. TP is identical to the platelet-derived endothelial cell growth factor with its angiogenic activity. Thus, it is believed that TP activity in tumor ti