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Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

✍ Scribed by Masakazu Toi; Seigo Hosnina; Tadaaki Taniguchi; Yutaka Yamamoto; Hideo Ishitsuka; Takeshi Tominaga

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
588 KB
Volume
64
Category
Article
ISSN
0020-7136

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✦ Synopsis

We have investigated the expression of platelet-derived endothelial-cell growth factorkhymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/ dThdPase monoclonal antibody. Out of I00 invasive-ductal-carcinoma tissue samples, 39 (39%) were evaluated as PD-ECGF/dThdPasepositive. The expression of PD-ECGF/dThdPase was identified mainly in the cytoplasma of tumor cells. The expression of PD-ECGF/dThdPase was significantly associated with the microvessel density assessed by immunostaining to factor-VIIIrelated-antigen (p < 0.05). However, there was no correlation between expression of PD-ECGF/dThdPase and menopausal status, tumor size, axillary lymph-node metastases, hormonereceptor status, epidermal-growth-factor receptor, or erb-B-2protein and p53-protein expression. We suggest that expression of PD-ECGF/dThdPase plays an important role in the promotion of angiogenesis in human breast cancer.

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