✦ LIBER ✦

Thymidine phosphorylase activity in nonsmall cell lung carcinoma tissues

✍ Scribed by Tokujiro Yano; Sadanori Takeo

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 114 KB
Volume: 92
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20011115)92:10<2658::aid-cncr1619>3.0.co;2-3

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✦ Synopsis

BACKGROUND. This is the first study on the quantitative assessment of thymidine phosphorylase (TP) activity in patients with nonsmall lung carcinoma. TP is identical to the platelet-derived endothelial cell growth factor with its angiogenic activity. Thus, it is believed that TP activity in tumor tissues plays an important role in disease progression.

METHODS.

Using a sandwich enzyme immunoassay, the TP activity in lung carcinoma tissues was measured quantitatively in 39 patients with primary lung carcinoma who underwent pulmonary lobectomy between July 1999 and May 2000.

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