Ornithine aminotransferase (OAT), a mitochondrial matrix enzyme, is deficient in patients with gyrate atrophy of the choroid and retina. In human, the OAT structural gene maps to Chromosome (Chr) 10q26 and several OAT-related sequences, some of which are known to be processed pseudogenes, which map
Localization of the ornithine aminotransferase gene and related sequences on two human chromosomes
β Scribed by Vijaya Ramesh; Roger Eddy; Gail A. Bruns; Vivian E. Shih; Thomas B. Shows; James F. Gusella
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 572 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Four related genes, Shaker, Shab, Shaw, and Shal, encode voltage-gated K Β§ channels in Drosophila. Multigene subfamilies corresponding to each of these Drosophila genes have been identified in rodents and primates; this suggests that the four genes are older than the common ancestor of present-day i
We have used a cDNA clone for human phosphoglycerate kinase (PGK) to examine the chromosomal localization of three members of the human PGK gene family. Using somatic cell hybrids segregating portions of several X-autosome translocations as well as a clone panel of hybrids segregating radiation-indu
We have isolated, sequenced, and determined the chromosomal localization of the gene encoding human lymphotoxin (LT). The single copy gene was isolated from a human genomic library using a "P-labeled 116 bp synthetic DNA fragment whose sequence was based on the NHz-terminal amino acid sequence of LT
A molecular probe containing a 584 base pairs sequence corresponding to part of the human calcitonin mRNA was used for the chromosomal assignment of the calcitonin gene. Restriction endonuclease analysis of DNA from human-Chinese hamster and human-mouse somatic cell hybrids, including some containin