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Localization of the polymorphic human calcitonin gene on chromosome 11

✍ Scribed by J. W. M. Höppener; P. H. Steenbergh; J. Zandberg; E. Bakker; P. L. Pearson; A. H. M. Geurts van Kessel; H. S. Jansz; C. J. M. Lips

Publisher
Springer
Year
1984
Tongue
English
Weight
728 KB
Volume
66
Category
Article
ISSN
0340-6717

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✦ Synopsis

A molecular probe containing a 584 base pairs sequence corresponding to part of the human calcitonin mRNA was used for the chromosomal assignment of the calcitonin gene. Restriction endonuclease analysis of DNA from human-Chinese hamster and human-mouse somatic cell hybrids, including some containing a translocation of human chromosomes, placed the calcitonin gene in the p14----qter region of chromosome 11. Analysis of human DNA showed that the calcitonin gene has a polymorphic site for restriction endonuclease TaqI.

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