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Localization of the human G-CSF gene to the region of a breakpoint in the translocation typical of acute promyelocytic leukemia

✍ Scribed by R. N. Simmers; J. Smith; M. F. Shannon; G. Wong; A. F. Lopez; E. Baker; G. R. Sutherland; M. A. Vadas

Publisher
Springer
Year
1988
Tongue
English
Weight
403 KB
Volume
78
Category
Article
ISSN
0340-6717

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D N A studies of the translocation t( 15; 17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosorne I7 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints have been mapped to1 3 clusters: bcr I, bcr2