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Analysis of the breakpoints in translocation (15;17) Observed in 4 patients with acute promyelocytic leukemia

✍ Scribed by A. Hagemeijer; B. Löwenberg; J. Abels

Publisher
Springer
Year
1982
Tongue
English
Weight
416 KB
Volume
61
Category
Article
ISSN
0340-6717

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D N A studies of the translocation t( 15; 17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosorne I7 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints have been mapped to1 3 clusters: bcr I, bcr2