High resolution breakpoints of the Philadelphia translocation in patients with chronic myelogenous leukemia
β Scribed by Shinichi Misawa; Shoichiro Tsuda; Masafumi Taniwaki; Tatsuro Takino; Tatsuo Abe
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 595 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1435-232X
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We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-
## Background: Patients with chronic myelogenous leukemia (cml) occasionally experience persistent thrombocythemia despite having adequate white blood cell (wbc) counts. trimethylenethiophosphoramide (thiotepa) is an alkylating agent that significantly inhibits platelet production. ## Methods: Th
Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o