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Philadelphia-positive chronic myelogenous leukemia with breakpoint 5? of the breakpoint cluster region but within the bcr gene

✍ Scribed by Bartram, Claus R. ;Bross-Bach, Ulrike ;Schmidt, Helmuth ;Waller, Hans D.

Publisher
Springer-Verlag
Year
1987
Weight
545 KB
Volume
55
Category
Article
ISSN
1432-0584

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✦ Synopsis

We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot analysis identified a chimeric 8 kb bcr/abl RNA transcript in leukemic cells. These data suggest that 1. less bcr coding sequences than previously assumed may be essential for the putative transforming activity of the rearranged bcr/abl gene and 2. the bcr probes currently used for diagnostic purposes could miss Ph-positive CML cases.

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Location of breakpoints within the major
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