Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15
✍ Scribed by A. Geurts Kessel; H. Leeuw; E. J. Dekker; L. Rijks; N. Spurr; D. Ledbetter; E. Kootwijk; M. J. Vaessen
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 487 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
A human genomic fragment comprising the cellular retinoic acid binding protein (CRABP) gene was isolated. By using a panel of somatic cell hybrids, this gene could be assigned to human chromosome 15. Subsequently, a possible involvement of the CRABP gene in translocation (15;17) (q22;q11) positive acute promyelocytic leukemia (APL) was investigated. Although transposition of the CRABP gene could be demonstrated, we did not observe any gross CRABP rearrangement in a series of primary APL patients, nor in the acute myeloblastic leukemia cell line HL-60. Thus, the observed lack of CRABP expression in these leukemic cells may not be caused by disruption of its gene. CRABP maps to the region 15q22-qter.