✦ LIBER ✦

Localization and imaging of radiolabelled monoclonal antibody against squamous-cell carcinoma of the head and neck in tumor-bearing nude mice

✍ Scribed by J. J. Quak; A. J. M. Balm; J. G. P. Brakkee; R. J. Scheper; H. J. Haisma; B. J. M. Braakhuis; C. J. L. M. Meijer; G. B. Snow

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 693 KB
Volume: 44
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910440327

No coin nor oath required. For personal study only.

✦ Synopsis

Nude mice carrying human squamous-cell carcinoma xenografts were given i.v. injections of radiolabelled monoclonal antibodies (Mas). MAb E 48, which reacts with squamouscell carcinomas, was labelled with i3'l, while a second control MAb of similar immunoglobulin subclass was labelled with lZ5l. Both antibodies were injected simultaneously, then the mice were scanned with a gamma camera or their tissues were removed uptake was calculated as a percentage of the Uptake of E 48 reached a peak value of I6%/g e uptake of the control antibody was less than 1.8%/g. By 24 hr after injection tumor could be visualized without subtraction techniques. At days 3 and 7, isible on imaging. These findings sugle of high specificity in targeting isocarcinomas in an experimental setting.

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