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Squamous cell carcinoma of the head and neck heterotransplanted to nude mice: Take rate in relation to patient survival

✍ Scribed by Ulf K. Zätterström; Johan Wennerberg; Robyn Attewell; Anders Ask

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
603 KB
Volume
66
Category
Article
ISSN
0008-543X

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✦ Synopsis

Biopsy specimens from 62 human single primary squamous cell carcinomas (SCC) of the head and neck were xenografted into nude mice. To evaluate the prognostic significance of successful heterotransplantation, the 62 cases were retrospectively examined for survival, adjusting for possible confounders by multivariate analysis. The recorded take rate in the first passage was 24'/0. Median survival in the take group was 25 months versus 74 months in the nontake group, which is not statistically significant in this material. However, the numerical difference in survival between the take groups is in accordance with the concept that human tumors accepted as xenografts on nude mice may constitute a selected group of malignancies. This has to be considered when using heterotransplanted human tumors for in vivo investigations of SCC of the head and neck. Cancer 66:145-151,1990.

UMAN TUMORS were first heterotransplanted to H congenital athymic, nude mice in 1969,' thereby providing a useful model for in vivo studies of human malignant tumors. Nude mice lack T-lymphocytes but are not totally devoid of immune defense; the resistance of both natural killer cells and macrophages have to be overcome by the transplanted A general observation is that only a certain percentage of the attempted heterotransplantations succeed in the first passage and even fewer tumors eventually establish tumor lines, i.e., grow for more than three generations on the animal^.^-^

The frequency of tumor "take" is dependent of tumor origin, tumor size, histologic type, and grade of malign a n ~y . ~

The acceptance rate also differs between heterotransplanted primary tumors on one hand and metastatic or recurrent tumors on the other, ie., take rates are higher From the

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