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Tumor angiogenesis and prognosis in squamous cell carcinoma of the head and neck

✍ Scribed by Dr. Ulf K. Zätterström; Dr. Eva Brun; Dr. Roger Willén; Dr. Elisabeth Kjellén; Dr. Johan Wennerberg

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
620 KB
Volume
17
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. The progression of tumor growth requires the recruitment of new blood vessels. It has been suggested that the degree of neovascularization would correlate with clinical prognosis. The purpose of the present study was to ascertain whether tumor vascularization correlated with clinical outcome in cases of primary squamous cell carcinoma of the head and neck (SCCHN).

Merfiods.

In tumor biopsies from 48 patients, microvessel density was determined by immunohistochemistry based on polyclonal antibodies against factor Vlll related endothelial antigen. Computerized image analysis was used to evaluate the staining intensity per histologic area. The degree of staining was quantitated and expressed as microvessel density, low and high microvessel density subgroups being compared with regard to survival.

From the Departments of Oto-rhino-laryngology (Drs. ZBtterstrdm and Wennerberg), Oncology (Drs. Brun and Kjellen), and Pathology (Dr.

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