Cell kinetics and tumor regression during radiotherapy in head and neck squamous-cell carcinomas

✍ Scribed by Renzo Corvo; Walter Giaretti; Elio Geido; Giuseppe Sanguineti; Roberto Orecchia; Marco Scala; Giacomo Garaventa; Enzo Mora; Vito Vitale

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 586 KB
• Volume: 68
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19961009)68:2<151::aid-ijc1>3.0.co;2-x

✦ Synopsis

Department of Radiotherapy, 2Laboratoty of Biophysics-Cytometry and 3Department of Surgery, National Institute for Cancer Head and neck sqwmous-cell carcinoma (HN-SCC) patient management is mainly based on TNM classification and needs be improved by considering other potentially useful prognostic factors. We examined the pre-radiotherap tumor potential doubling time u? evaluated after in vivo idsion of bromodeoxyuridine and ow-cytometric analysis and the early clinical tumor regression after 40 Gy (40 Gy-TR). Tpot values and clinical 40 Gy-TR classes (minor and major) were available for 82 HN-SCC patients. Radiation therapy completion was done either with I dose per day (conventional regimen) or 2 doses per day (accelerated regimen). Local control was also available for follow-up times above 4 years. We found that major 40 Gy-TR was strongly correlated with fast tumor growth. characterized by T, values below 5 days, and that patients with major 40 Gy-TR showed better local control than those with minor 40 Gy-TR, independently from the radiotherapy regimen type. We also found that treatment completion with accelerated radiotherapy gave better local control for patients with major 40 Gy-TR and fast tumor growth than conventional radiotherapy. Multivariate analysis, performed on all patients, assigned an independent prognostic value to TWr tumor classification and 40 Gy-TR