✦ LIBER ✦

Postradiotherapy neck dissection for head and neck squamous cell carcinoma: Pattern of pathologic residual carcinoma and prognosis

✍ Scribed by Miriam N. Lango; Genevieve A. Andrews; Sidrah Ahmad; Steven Feigenberg; Madalina Tuluc; John Gaughan; John A. Ridge

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 177 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.20976

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

For patients with head and neck cancer who were treated using primary radiotherapeutic approaches, the pattern of pathologic residual carcinoma in the neck dissection specimen and its effect on clinical outcome remains unknown.

Methods

Medical records of 65 patients who underwent 71 neck dissections a median 7 weeks after radiotherapy were reviewed. Median follow‐up was 33 months.

Results

Residual cancer, identified in 28 patients (43%), diminished locoregional control (p = .018), recurrence‐free (p = .018), and overall survival (p = .02). Thirteen patients (20%) had 2 or more pathologically involved lymph nodes. Nine (13%) involved level V. Four (6%) had pathologic involvement of nodal levels not clinically involved by cancer before treatment. In N2‐3 patients with positive pathologic specimens, the presence of these factors diminished recurrence‐free survival (p = .01). The outcome of patients with pathologic carcinoma but without such ominous factors approached those with negative pathology.

Conclusions

📜 SIMILAR VOLUMES

Planned neck dissection after definitive

Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck

✍ William M. Mendenhall; Douglas B. Villaret; Robert J. Amdur; Russell W. Hinerman 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 2 views

## Abstract ## Background. To define the role of planned neck dissection after definitive radiotherapy for patients with node‐positive squamous cell carcinoma of the head and neck. ## Methods. Review of the pertinent literature. ## Results. Radiotherapy alone produces a relatively high likelih

Radiotherapeutic management of bulky cer

Radiotherapeutic management of bulky cervical lymphadenopathy in squamous cell carcinoma of the head and neck: Is Postradiotherapy Neck Dissection Necessary?

✍ Christopher R. Johnson; Larry N. Silverman; Louise B. Clay; Rupert Schmidt-Ullri 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 88 KB 👁 3 views

Although traditional recommendations for the management of bulky cervical lymphadenopathy (AJCC categories N2-3) with definitive radiotherapy call for postradiotherapy neck dissection regardless of treatment response, recent data suggests that this policy can be modified on the basis of tumor regres

Postradiotherapy surveillance practice f

Postradiotherapy surveillance practice for head and neck squamous cell carcinoma—too much for too little?

✍ David L. Schwartz; Jerry Barker Jr; Kari Chansky; Bevan Yueh; Leila Raminfar; Pa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

## Abstract ## Introduction. Limited information is available regarding surveillance patterns after head and neck cancer radiotherapy. We cataloged follow‐up for a specified patient cohort treated at three neighboring university, community, and Veterans Administration institutions. ## Methods. O

Extent of neck dissection required after

Extent of neck dissection required after concurrent chemoradiation for stage IV head and neck squamous cell carcinoma

✍ Steven B. Cannady; Walter T. Lee; Joseph Scharpf; Robert R. Lorenz; Benjamin G. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 2 views

## Abstract ## Background The management of initially bulky nodal disease after primary nonsurgical treatment for stage IV head and neck squamous cell carcinoma (HNSCC) continues to be a subject of debate. ## Methods A retrospective chart review of neck management in patients after chemoradiatio

Mouse models for human head and neck squ

Mouse models for human head and neck squamous cell carcinomas

✍ Shi-Long Lu; Heather Herrington; Xiao-Jing Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB 👁 1 views

Proteomics: Clinical applications for he

Proteomics: Clinical applications for head and neck squamous cell carcinoma

✍ Wendell G. Yarbrough; Robbert J. C. Slebos; Daniel Liebler 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB 👁 2 views

The emerging field of proteomics offers great promise for unraveling the complex molecular events of tumorigenesis, as well as those that control clinically important tumor behaviors such as metastases, invasion, and resistance to therapy. Understanding the molecular basis of these tumor characteris