Lipoxins A4 and B4 inhibit leukotriene B4 generation from human neutrophil leukocyte suspensions
β Scribed by Pio Conti; Marcella Reale; Renato C. Barbacane; Mauro Bongrazio; Maria R. Panara
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 466 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0165-2478
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Leukotriene B4 (LTB4) has been shown to affect several interleukin (1L)-linked functions of human lymphocytes. In this study, we investigated whether LTBj regulates IL-5 generation from human T cells and subsequently modulates eosinophil functions. Preincubation of T cells with very low concentratio
A total convergent synthesis of lipoxins A4 and B4 has been carried out via four optically pure a-hydroxy and a$-dihydroxyaldehydes, obtained from D-isoascorbic acid as a single starting material. Connection by a six carbons unit uses Wittig-type reactions notably involving a stabilized arsonium yl