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Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome

✍ Scribed by Korade, Zeljka; Xu, Libin; Mirnics, Karoly; Porter, Ned A.

Book ID
118796593
Publisher
Springer
Year
2012
Tongue
English
Weight
485 KB
Volume
36
Category
Article
ISSN
0141-8955

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The fact that Smith-Lemli-Opitz syndrome (SLOS), a syndrome comprising major malformations involving a number of organ systems, results from an abnormality in cholesterol biosynthesis, was discovered only recently. Utilizing a drug (BM 15.766) to inhibit the same step in cholesterol biosynthesis as