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Hepatic Isoprenoid Metabolism in a Rat Model of Smith-Lemli-Opitz Syndrome

✍ Scribed by R. Kennedy Keller, David A. Mitchell, Christopher C. Goulah, Steven J. Fliesler

Book ID
120949203
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
394 KB
Volume
48
Category
Article
ISSN
0024-4201

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The fact that Smith-Lemli-Opitz syndrome (SLOS), a syndrome comprising major malformations involving a number of organ systems, results from an abnormality in cholesterol biosynthesis, was discovered only recently. Utilizing a drug (BM 15.766) to inhibit the same step in cholesterol biosynthesis as