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Establishment of Oxysterol Biomarkers in a Mouse Model of Smith-Lemli-Opitz Syndrome and the Effect of Antioxidant Supplementation

✍ Scribed by Xu, Libin; Korade, Zeljka; Mirnics, Karoly; Porter, Ned A.


Book ID
121944776
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
203 KB
Volume
53
Category
Article
ISSN
0891-5849

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Clinical effects of cholesterol suppleme
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We describe the clinical effects of cholesterol supplementation in 6 children with the RSH-"Smith-Lemli-Opitz" syndrome (SLOS). The children ranged in age from birth to 11 years at the onset of therapy, with pretreatment cholesterol levels ranging from 8 to 62 mg/dl. Clinical benefits of therapy wer