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Lipase-catalyzed asymmetric hydrolysis of esters having remote chiral/prochiral centers

✍ Scribed by Hughes, David L.; Bergan, J. J.; Amato, J. S.; Bhupathy, M.; Leazer, J. L.; McNamara, J. M.; Sidler, D. R.; Reider, P. J.; Grabowski, E. J. J.


Book ID
127279436
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
970 KB
Volume
55
Category
Article
ISSN
0022-3263

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ChemInform Abstract: Asymmetric Synthesi
✍ Yasushi Kawai; Kouichi Hida; Duc Hai Dao; Atsuyoshi Ohno πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 1 views

Asymmetric Synthesis of Ξ²-Hydroxy Esters Having Three Consecutive Chiral Centers with a Reductase from Bakers' Yeast. -The title reaction is investigated with Ξ²-keto esters (I) having a secondary alkyl group at the Ξ±-position. The corresponding Ξ²-hydroxy esters can be isolated in excellent enantios