Lipase-catalyzed production of optically active acids via asymmetric hydrolysis of esters
β Scribed by Bernard Cambou; Alexander M. Klibanov
- Book ID
- 112896255
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 331 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0273-2289
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## Abstract Both enantiomers of the six major kinds of __Ξ³__βlactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__β__N__βmethylβ4βhydroxyalkanamides via Grignard reaction and the enantioselective acetylatio
Preparation of Optically Active Photopyridone by Lipase-Catalyzed Asymmetric Resolution. -The title compounds are prepared by lipase-catalyzed enantioselective acylation or hydrolysis of racemic photopyridones (IV) and (X). The absolute configurations are determined by chemical correlations, X-ray