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Synthesis of optically active γ-lactones via lipase-catalyzed resolution

✍ Scribed by Yasutaka Shimotori; Yukihiko Nakahachi; Keita Inoue; Tetsuo Miyakoshi

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
326 KB
Volume
22
Category
Article
ISSN
0882-5734

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✦ Synopsis

Abstract

Both enantiomers of the six major kinds of γ‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various rac‐N‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylation and hydrolysis promoted by Novozym 435. Copyright © 2007 John Wiley & Sons, Ltd.

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