𝔖 Bobbio Scriptorium
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Lipase-catalysed resolution of hydroxy sulfones

✍ Scribed by Rafael Chinchilla; Carmen Nájera; José Pardo; Miguel Yus


Book ID
103976877
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
228 KB
Volume
1
Category
Article
ISSN
0957-4166

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Lipases A and B from Candida antarctica are shown to be highly efficient and complementary biocatalysts for the resolution of five-to seven-membered cyclic b-hydroxy esters by O-acylation. Using this procedure, all four stereoisomers of each one are obtained in enantiopure form and very high yields.

Lipase-catalysed kinetic resolution of h
✍ A. Czompa; T. Kovács; S. Antus 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 300 KB

## Abstract An effective kinetic resolution of hydroxymethylchromanes racemic **2a** and **3a** has been achieved by means of enantioselective transesterification with vinyl acetate in organic solvents. The alcohols (‐)‐__R__‐**2a** and (‐)‐__S__‐**3a** were obtained with high optical purities (94