A successful one-pot reduction of g-ketoesters, d-ketoesters and lactones to the corresponding 1,4-and 1,5-diols followed by a lipase catalyzed kinetic resolution coupled with hydrolysis to afford optically active diols is described. The synthetic utility of this one-pot method was illustrated by th
Lipase-catalysed resolution of γ- and δ-lactones
✍ Scribed by Markus M Enzelberger; Uwe T Bornscheuer; Ian Gatfield; Rolf D Schmid
- Book ID
- 119524772
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 72 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0168-1656
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📜 SIMILAR VOLUMES
## Abstract Both enantiomers of the six major kinds of __γ__‐lactones were synthesized to >98% e.e. in four steps, starting from succinic anhydride. The key features were the syntheses of the various __rac__‐__N__‐methyl‐4‐hydroxyalkanamides via Grignard reaction and the enantioselective acetylatio
o-Trimethylsilyloxy-a-diazo-b-ketophosphonates were prepared in two steps from g-lactones. After exposure to catalytic rhodium(II) in refluxing toluene and further aqueous treatment, they gave rise to a-phosphono-d-lactones in moderate to good yields.