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Lipase-catalysed resolution of cyclic cis- and trans-β-hydroxy esters

✍ Scribed by Laura M. Levy; Juan R. Dehli; Vicente Gotor

Book ID
104359893
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
186 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

Lipases A and B from Candida antarctica are shown to be highly efficient and complementary biocatalysts for the resolution of five-to seven-membered cyclic b-hydroxy esters by O-acylation. Using this procedure, all four stereoisomers of each one are obtained in enantiopure form and very high yields.

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Lipase-catalysed resolution of cis-1-ethoxycarbonyl-2-hydroxy-cyclohexane: Enantioselective total synthesis of 10-ethyl-trinem
✍ Mauro Panunzio; Roberto Camerini; Andrea Mazzoni; Daniele Donati; Carla Marchior 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 167 KB

Pseudomonas fluorescens lipase (PFL) was used as catalyst for enzymatic resolution of 1-ethoxycarbonyl-2-hydroxy-cyclohexane. The resulting ester was used for the total synthesis of the novel enantiomerically pure 10-ethyl trinem.