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Lipase-catalysed resolution of cis-1-ethoxycarbonyl-2-hydroxy-cyclohexane: Enantioselective total synthesis of 10-ethyl-trinem

✍ Scribed by Mauro Panunzio; Roberto Camerini; Andrea Mazzoni; Daniele Donati; Carla Marchioro; Roberta Pachera

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 167 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(96)00489-2

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✦ Synopsis

Pseudomonas fluorescens lipase (PFL) was used as catalyst for enzymatic resolution of 1-ethoxycarbonyl-2-hydroxy-cyclohexane. The resulting ester was used for the total synthesis of the novel enantiomerically pure 10-ethyl trinem.

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