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Linkage study of the dopamine D5 receptor gene and Gilles de la Tourette syndrome

✍ Scribed by Barr, Cathy L.; Wigg, Karen G.; Zovko, Elizabeth; Sandor, Paul; Tsui, Lap-Chee

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
97 KB
Volume
74
Category
Article
ISSN
0148-7299

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✦ Synopsis

A defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D 5 receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for linkage to the dopamine D 5 receptor gene using a microsatellite polymorphism located in the same cosmid clone. Using an autosomal dominant model with reduced penetrance, we were able to exclude linkage in four of the five families for the TS and chronic multiple tics (CMT) phenotype. Also, no evidence for linkage was found using nonparametric methods in all five families. Am.

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