A defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D 5 receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for l
Evaluation of the genes for the adrenergic receptors ?2A and ?1C and Gilles de la Tourette Syndrome
β Scribed by Xu, Chun ;Ozbay, Fatih ;Wigg, Karen ;Shulman, Rayzie ;Tahir, Eda ;Yazgan, Yanki ;Sandor, Paul ;Barr, Cathy L. ;,
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 73 KB
- Volume
- 119B
- Category
- Article
- ISSN
- 0148-7299
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Gilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics affecting approximately 1/10,000 females and 1/2000 males. Because of the success of neuroleptics and other agents interacting with the dopaminergic system in the suppression of tics, a defe
## Abstract Numerous lines of evidence support the role of the catecholamines in the development of tics and Gilles de la Tourette syndrome (GTS). DopamineβΞ²βhydroxylase (DBH) is the key enzyme in the conversion of dopamine to norepinephrine and the alleles of several polymorphisms of the __DBH__ g
Genetic imprinting refers to the phenomenon whereby the precise expression of a specific trait (or disease) may depend on the sex of the transmitting parent. The purpose of the present project was to investigate the possibility for the involvement of genetic imprinting in Tourette syndrome (TS), a d