Linkage of genes for chronic granulomatous disease and Xg
✍ Scribed by G. Wolff; C. R. Müller; A. Jobke
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 208 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0340-6717
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A luminol enhanced chemiluminescence micromethod has been adapted for use in prenatal diagnosis of chronic granulomatous disease (CGD). After validation of the assay in normal adults, newborns, fetuses, CGD carriers, and CGD patients, the fetuses of two pregnant CGD carriers were tested after fetosc
The most frequent form of chronic granulomatous disease (CGD) is caused by inactivation of the CYBB gene, which encodes the gp91-phox subunit of phagocyte NADPH oxidase. This defect prevents phagocytes from producing reactive oxygen species and thus from eradicating bacterial and fungal infections.